
Get a Zoryve prescription online
No appointments required
$15 consult—no membership required
Medical review within 3 hours
Zoryve is a non-steroidal psoriasis treatment. Available as a one-daily topical cream, this phosphodiesterase-4 (PDE-4) inhibitor helps clear up psoriasis patches and reduces inflammation.
See what others are saying about Dr. B

How Dr. B treats psoriasis
Tell us about your condition with a $15 online consultation.
A medical provider will review your information and prescribe treatment, if appropriate.
Pick up and pay for the medication at the pharmacy of your choice. Or, get it delivered.
About Zoryve
How does it work?
Zoryve is a steroid-free PDE4 inhibitor medication. It works by increasing cyclic adenosine monophosphate (AMP) levels, which play a role in increasing the inflammation that triggers psoriasis, relieving symptoms like dryness, rashes, and plaques.
What does it treat?
Zoryve treats the scaly, itchy patches of psoriasis. It improves these symptoms by restricting the activity of the PDE-4 protein, which causes skin inflammation.
What forms does it come in?
This psoriasis treatment is available as a topical cream that you apply to the affected area of skin, usually once daily.
Zoryve vs. Calcipotriene
Zoryve blocks a specific protein that causes skin inflammation, calming and clearing psoriasis patches. Calcipotriene works differently to slow the growth of skin cells and relieve symptoms like itching, scaling, and redness. Both are safe and effective psoriasis treatments.
Side Effects

Not everyone experiences side effects when prescribed this medication. When they do occur, they’re often mild. Possible side effects include:
- Diarrhea
- Nausea
- Headache
- Trouble sleeping
If you experience severe side effects like a serious allergic reaction or seizure—or other new and worrying symptoms—contact your health provider or pharmacist immediately.
More Psoriasis Prescription Treatments
Looking for a different medication? Here are some options.
Common Questions
Zoryve prescription FAQ
What are the benefits of using Zoryve?
- Reduces inflammation
- Encourages healing
- Eases itching
Who should not use this medication?
- Those allergic to it or its ingredients
- Those who have moderate or severe liver disease
- Those who are pregnant or breastfeeding
- Those who are taking certain other medications, including Theophylline or Ketoconazole
If you have any of these conditions, speak with a licensed provider before using this psoriasis treatment.
How do I use this medication?
In most cases, you apply the cream to the affected areas of your skin once a day. Carefully follow your provider’s instructions for optimal results.
What happens if I miss a dose?
If you miss a dose of Zoryve, take it when you remember. If it’s almost time for the next dose, skip the missed dose and return to your regular schedule. Do not double your dose.
What happens if I use too much?
Taking more of this medication than directed can cause serious side effects such as nausea, vomiting, diarrhea and dizziness.
If you’ve taken too much, call your healthcare provider or local poison control center (800-222-1222) right away.
Can I get Zoryve online?
Yes! Qualifying patients can get a prescription for Zoryve online by taking a convenient Dr. B $15 consultation. A licensed medical provider will review your symptoms and health history. If you qualify for treatment, they'll send your online Zoryve prescription to your pharmacy of choice.
Medically reviewed
“I love direct contact with patients—it’s why I chose dermatology! With ample time together, I can use my eyes and mind to diagnose their condition, like a sleuth!”
