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Roflumilast is a popular psoriasis prescription. Available as a topical cream, this medication is a phosphodiesterase-4 (PDE-4) inhibitor that can help clear patches and reduce inflammation.
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A medical provider will review your information independently or during a brief video visit and prescribe treatment if appropriate.
Pick up and pay for the medication at the pharmacy of your choice. Or, get it delivered.
About Roflumilast
How does it work?
This medication blocks a protein called PDE-4, thought to play a role in inflammation. This medication helps relieve psoriasis symptoms such as rashes, dryness and plaques.
What does it treat?
This medication treats psoriasis, a skin disease characterized by scaly, itchy patches. It improves symptoms by restricting activity of the PDE-4 protein.
What forms does it come in?
This psoriasis treatment is available as a topical cream that you apply to the affected area of skin.
Roflumilast vs. Calcipotriene
Roflumilast is a cream medication that blocks a specific protein that causes skin inflammation, so inflammation calms and psoriasis patches clear up. Calcipotriene is a non-steroidal medication that works differently to slow the growth of skin cells and relieve symptoms like itching, scaling and redness.
Side Effects

Not everyone experiences side effects when prescribed this medication. When they do occur, they’re often mild. Possible side effects include:
- Diarrhea
- Nausea
- Headache
- Trouble sleeping
If you experience severe side effects like a serious allergic reaction or seizure—or other new and worrying symptoms—contact your health provider or pharmacist immediately.
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Common Questions
Roflumilast prescription FAQ
What are the benefits of using Roflumilast?
- Reduces inflammation
- Encourages healing
- Eases itching
Who should not use this medication?
- People who are allergic to it or its ingredients
- People who have moderate or severe liver disease
- People who are pregnant or breastfeeding
- People who are taking certain other medications, including Theophylline or Ketoconazole
If you have any of these conditions, speak with a licensed provider before using this psoriasis treatment.
How do I use this medication?
In most cases, you apply the cream formulation to the affected areas of skin once a day. Follow your medical provider’s instructions carefully for best results.
What happens if I miss a dose?
If you miss a dose of Roflumilast, take it when you remember. If it’s almost time for the next dose, skip the missed dose and return to your regular schedule. Do not double your dose.
What happens if I use too much?
Taking more of this medication than directed can cause serious side effects such as nausea, vomiting, diarrhea and dizziness.
If you’ve taken too much, call your healthcare provider or local poison control center (800-222-1222) right away.
Can I get Roflumilast online?
You can get this medication online through a confidential Dr. B $15 online consultation. A licensed medical provider will review your information and, if you qualify for treatment, send an online prescription or refill to your pharmacy of choice.
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